// company-profile

Upstream Bio, Inc.

UPB
ExchangeNasdaqSectorPharmaceutical PreparationsInc.DEFilings43Insiders21
// api This Upstream Bio, Inc. insider-trading data is served live by the Form4API insider trading API. Get the same data via API.

// activity-summary

Recent insider activity is bullish. Over the last 30 days, 6 insiders purchased shares versus 5 sales. Buying was led by Beckman Daniella.

// 90-day insight

Over the last 90 days, Upstream Bio, Inc. insiders bought $0 (6 transactions) and sold $31K (5 transactions).

  • Most active insider: Sutherland Everett Rand with 1 transaction totaling $13K.
  • Largest single sale: $13K by Sutherland Everett Rand on Jun 16, 2026.

Activity is mixed — buys and sales are roughly balanced.

Institutional Ownership

Top 13F-HR holders of Upstream Bio, Inc. as of 2026-03-31

↓ decreasing
Total reported AUM
$391.5M
QoQ change
-69.9%
Reporting period
2026-03-31
#1
FMR LLC
CIK 315066
$64.9M
7.2M shares
#2
ORBIMED ADVISORS LLC
CIK 1055951
$51.2M
5.7M shares
#3
Decheng Capital LLC
CIK 2010850
$24.5M
2.7M shares

Data source: SEC Form 13F-HR filings. Joined with insider activity above — see who's loading up institutionally while insiders are trading. Full 13F-HR API →

Insider Transactions

Sourced from SEC EDGAR Form 4 filings. Updated hourly.

DateInsiderCompanyTypeSharesPriceValue
Jun 16, 2026Deykin AaronUPB
Sale
895$6.10$5K
Jun 16, 2026Ambrose AllisonUPB
Sale
477$6.10$3K
Jun 16, 2026GRAY MICHAELUPB
Sale
853$6.10$5K
Jun 16, 2026Sutherland Everett RandUPB
Sale
2,095$6.10$13K
Jun 16, 2026Houghton AdamUPB
Sale
700$6.10$4K

45 more transactions hidden

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