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Company profile

Upstream Bio, Inc. Insider Trading

UPB

Every SEC Form 4 insider trading filing for Upstream Bio, Inc. (UPB) since April 2023 — open-market buys and sells by directors and officers, option exercises, and cluster activity, updated as each filing is reported to the SEC. Why 2023?

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
CIK
0002022626
Filings
48
Insiders
21
Last filing
2026-09-16
SEC EDGAR ↗Yahoo Finance ↗Finviz ↗Stock Analysis ↗

Activity summary

Recent insider activity is bearish. Over the last 30 days, insiders net sold $28K across 5 transactions.

Three year balance

Buy and sell value by quarter, Q4 24 to Q3 26. Upstream Bio, Inc. insiders are net buyers across the period shown.

PurchasesSales
$48.0MQ4 24Q1 25Q2 25Q3 25Q4 25Q1 26Q2 26Q3 26

Bars below the rule are sales, above are purchases. Largest quarter on the chart is $48.0M.

90 day insight

Over the last 90 days, Upstream Bio, Inc. insiders sold $28K across 5 transactions with no open-market purchases.

  • Most active insider: Everett Rand Sutherland with 1 transaction totaling $12K.
  • Largest single sale: $12K by Everett Rand Sutherland on Sep 16, 2026.

Activity skews bearish — sales outpace buys.

Insider Transactions

Sourced from SEC EDGAR Form 4 filings. Updated hourly.

DateInsiderCompanyTypeSharesPriceValueReturn
Sep 16, 2026Michael GrayUPB
Sale
853$5.49$5KPending
Sep 16, 2026Adam HoughtonUPB
Sale
700$5.49$4KPending
Sep 16, 2026Everett Rand SutherlandUPB
Sale
2,095$5.49$12KPending
Sep 16, 2026Aaron DeykinUPB
Sale
895$5.49$5KPending
Sep 16, 2026Allison AmbroseUPB
Sale
485$5.49$3KPending

45 more transactions hidden

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Top insiders

By total value filed.

ORBIMED ADVISORS LLCDirector2 filings+$14.0M
Everett Rand SutherlandChief Executive Officer3 filings−$44K
Aaron DeykinChief Medical Officer3 filings−$19K
Michael GrayCFO and COO3 filings−$18K
Adam HoughtonChief Business Officer3 filings−$15K

Institutional Ownership

Top 13F-HR holders of Upstream Bio, Inc. as of 2026-06-30

↓ decreasing
Total reported AUM
$50.4M
QoQ change
-87.1%
Reporting period
2026-06-30
#1
BlackRock, Inc.
CIK 0002012383
$11.1M
1.6M shares
#2
BlackRock, Inc.
CIK 0002012383
$7.2M
1.0M shares
#3
SEB Asset Management AB
CIK 0002127509
$6.1M
878K shares

Data source: quarterly 13F-HR filings — institutional holders report positions within 45 days of quarter end. Joined with insider activity above — see who's loading up institutionally while insiders are trading. Full 13F-HR API →

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Form4API, StockholmNot affiliated with the SEC or EDGAR. Data sourced from public EDGAR filings. Not investment advice.

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