// company-profile
Spyre Therapeutics, Inc.
SYRE// activity-summary
Recent insider activity is bullish. Over the last 30 days, 6 insiders purchased shares. Buying was led by Milligan Sandra.
// 90-day insight
Over the last 90 days, Spyre Therapeutics, Inc. insiders bought $0 across 6 transactions with no open-market sales.
- Most active insider: Sloan Sheldon with 15 transactions totaling $9.2M.
- Largest single sale: $2.5M by HENDERSON MICHAEL THOMAS on May 8, 2026.
- 100% of recent sales were pre-scheduled 10b5-1 trades — typically less informative than open-market activity.
Activity skews bullish — buys outpace sales.
Institutional Ownership
Top 13F-HR holders of Spyre Therapeutics, Inc. as of 2026-03-31
Data source: SEC Form 13F-HR filings. Joined with insider activity above — see who's loading up institutionally while insiders are trading. Full 13F-HR API →
Insider Transactions
Sourced from SEC EDGAR Form 4 filings. Updated hourly.
| Date | Insider | Company | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 3, 2026 | Sloan Sheldon | SYRE | Sale10b5 | 8,333 | $75.00 | $625K |
| Jun 3, 2026 | Sloan Sheldon | SYRE | Option Exercise10b5 | 8,333 | $27.46 | $229K |
| Jun 3, 2026 | Sloan Sheldon | SYRE | Option Exercise10b5 | 8,333 | $0.00 | $0K |
| Jun 1, 2026 | Burrows Scott L | SYRE | Sale10b5 | 3,100 | $72.06 | $223K |
| Jun 1, 2026 | Burrows Scott L | SYRE | Option Exercise10b5 | 7,500 | $0.00 | $0K |
45 more transactions hidden
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