Company profile
Spyre Therapeutics, Inc. Insider Trading
SYREEvery SEC Form 4 insider trading filing for Spyre Therapeutics, Inc. (SYRE) since April 2023 — open-market buys and sells by directors and officers, option exercises, and cluster activity, updated as each filing is reported to the SEC. Why 2023?
- Exchange
- Nasdaq
- Sector
- Pharmaceutical Preparations
- CIK
- 0001636282
- Filings
- 81
- Insiders
- 20
- Last filing
- 2026-09-02
Activity summary
Recent insider activity is bearish. Over the last 30 days, insiders net sold $1.6M across 1 transaction.
Three year balance
Buy and sell value by quarter, Q4 23 to Q3 26. Spyre Therapeutics, Inc. insiders are net sellers across the period shown.
Bars below the rule are sales, above are purchases. Largest quarter on the chart is $420.2M.
90 day insight
Over the last 90 days, Spyre Therapeutics, Inc. insiders bought $218K (2 transactions) and sold $2.9M (3 transactions).
- Most active insider: Scott L Burrows with 20 transactions totaling $5.5M.
- Largest single sale: $1.6M by Scott L Burrows on Sep 2, 2026.
- 91% of recent sales were pre-scheduled 10b5-1 trades — typically less informative than open-market activity.
Activity skews bearish — sales outpace buys.
Insider Transactions
Sourced from SEC EDGAR Form 4 filings. Updated hourly.
| Date | Insider | Company | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Sep 2, 2026 | Heidy King-Jones | SYRE | Option Exercise10b5 | 400 | — | — |
| Sep 2, 2026 | Heidy King-Jones | SYRE | Sale10b5 | 400 | $90.00 | $36K |
| Sep 2, 2026 | Heidy King-Jones | SYRE | Option Exercise10b5 | 400 | $14.50 | $6K |
| Sep 2, 2026 | Scott L Burrows | SYRE | Sale | 18,232 | $89.35 | $1.63M |
| Sep 1, 2026 | Heidy King-Jones | SYRE | Option Exercise10b5 | 27,999 | $14.50 | $406K |
45 more transactions hidden
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Query this yourself
The same rows, over the API.
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-H "X-Api-Key: $KEY"Top insiders
By total value filed.
Institutional Ownership
Top 13F-HR holders of Spyre Therapeutics, Inc. as of 2026-06-30
Data source: quarterly 13F-HR filings — institutional holders report positions within 45 days of quarter end. Joined with insider activity above — see who's loading up institutionally while insiders are trading. Full 13F-HR API →