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Company profile

Spero Therapeutics, Inc. Insider Trading

SPRO

Every SEC Form 4 insider trading filing for Spero Therapeutics, Inc. (SPRO) since April 2023: open-market buys and sells by directors and officers, option exercises, and cluster activity, updated as each filing is reported to the SEC. Why 2023?

Exchange
Nasdaq
Sector
Pharmaceutical Preparations
CIK
0001701108
Filings
65
Insiders
14
Last filing
2026-08-03
SEC EDGAR ↗Yahoo Finance ↗Finviz ↗Stock Analysis ↗

Activity summary

No insider transactions in the last 30 days. The most recent was on August 3, 2026, when Debra Zack bought 162,311 shares. 65 filings from 14 insiders are on record below.

Three year balance

Buy and sell value by quarter, Q4 23 to Q3 26. Spero Therapeutics, Inc. insiders are net sellers across the period shown.

PurchasesSales
Q4 23Q1 24Q2 24Q3 24Q4 24Q1 25Q2 25Q3 25Q4 25$393KQ1 26Q2 26Q3 26

Bars below the rule are sales, above are purchases. Largest quarter on the chart is $393K.

90 day insight

Over the last 90 days, Spero Therapeutics, Inc. insiders bought $0 across 2 transactions with no open-market sales.

  • Most active insider: Debra Zack with 2 transactions totaling $0.

Activity skews bullish: buys outpace sales.

Insider Transactions

Sourced from SEC EDGAR Form 4 filings. Updated hourly.

DateInsiderCompanyTypeSharesPriceValueReturn
Aug 3, 2026Debra ZackSPRO
Award
162,311——-4.7% 1m
Aug 3, 2026Debra ZackSPRO
Award
324,675——-4.7% 1m
Jun 23, 2026John C Pottage JrSPRO
Award
10,000——-41.6% 1m
Jun 23, 2026John C Pottage JrSPRO
Award
20,000——-41.6% 1m
Jun 23, 2026Scott Thomas JacksonSPRO
Award
10,000——-41.6% 1m

45 more transactions hidden

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Top insiders

By total value filed.

Esther RajaveluSee Remarks6 filings−$423K
Timothy KeutzerChief Development Officer8 filings−$193K
Sath ShuklaCEO and President3 filings−$121K
Ankit Mahadevia3 filings−$67K

Institutional Ownership

Top 13F-HR holders of Spero Therapeutics, Inc. as of 2026-06-30

↓ decreasing
Total reported AUM
$4.0M
QoQ change
-91.5%
Reporting period
2026-06-30
#1
Alphabet Inc.
CIK 0001652044
$2.0M
890K shares
#2
BlackRock, Inc.
CIK 0002012383
$954,740
432K shares
#3
State Street Corp
CIK 0000093751
$474,600
215K shares

Data source: quarterly 13F-HR filings: institutional holders report positions within 45 days of quarter end. Joined with insider activity above: see who's loading up institutionally while insiders are trading. Full 13F-HR API →

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Form4API, StockholmNot affiliated with the SEC or EDGAR. Data sourced from public EDGAR filings. Not investment advice.

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